From Miami International Airport
From Miami International Airport, take LeJeune Road south to 836 West. Take the Florida Turnpike south toward Key West. The Turnpike ends at US 1 in Florida City. Follow U.S. 1 south about 22 miles to Key Largo and you are now in the Florida Keys.

From Ft. Lauderdale/Hollywood Airport
From Ft. Lauderdale-Hollywood International Airport, exit the airport and follow the signs for 595 West. Take 595 to the Florida Turnpike and follow the signs for the Florida Keys.

From North Florida
From the north, take the Florida Turnpike south to just below Ft. Lauderdale, where Exit 4 takes onto the southern portion of the Turnpike. The Turnpike ends at US 1 in Florida City. Follow U.S. 1 south into the Florida Keys.

From West Coast of Florida
From Florida’s west coast, take 1-75 Alligator Alley east to the Miami exit, and south to the Turnpike Extension.